Cellular and microenvironmental cues that promote macrophage fusion and foreign body response

During the foreign body response (FBR), macrophages fuse to form foreign body giant cells (FBGCs). Modulation of FBGC formation can prevent biomaterial degradation and loss of therapeutic efficacy. However, the microenvironmental cues that dictate FBGC formation are poorly understood with conflictin...

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Bibliographic Details
Main Authors: Stewart, CL, Hook, AL, Zelzer, M, Marlow, M, Piccinini, AM
Format: Journal article
Language:English
Published: Frontiers Media 2024