Histone recognition and large-scale structural analysis of the human bromodomain family.

Bromodomains (BRDs) are protein interaction modules that specifically recognize ε-N-lysine acetylation motifs, a key event in the reading process of epigenetic marks. The 61 BRDs in the human genome cluster into eight families based on structure/sequence similarity. Here, we present 29 high-resoluti...

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Bibliographic Details
Main Authors: Filippakopoulos, P, Picaud, S, Mangos, M, Keates, T, Lambert, J, Barsyte-Lovejoy, D, Felletar, I, Volkmer, R, Müller, S, Pawson, T, Gingras, A, Arrowsmith, C, Knapp, S
Format: Journal article
Language:English
Published: 2012