Two distinct cellular mechanisms of osteoclast formation and bone resorption in periprosthetic osteolysis.
PURPOSE: TNFalpha and IL-1alpha are proinflammatory cytokines that are abundant in periprosthetic tissues. These cytokines stimulate bone resorption and have recently been shown to directly induce osteoclast formation in mouse marrow cultures. We examined whether TNFalpha and IL-1alpha can directly...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2003
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