Spirocyclic systems derived from pyroglutamic acid.

The synthesis and likely conformational structure of rigid spirocyclic bislactams and lactam-lactones derived from pyroglutamic acid, and their suitability as lead structures for applications in drug development programmes using cheminformatic analysis, has been investgated.

Bibliographic Details
Main Authors: Cowley, A, Hill, T, Kocis, P, Moloney, M, Stevenson, R, Thompson, A
Format: Journal article
Language:English
Published: 2011