The structure of phosphorylase kinase holoenzyme at 9.9 angstroms resolution and location of the catalytic subunit and the substrate glycogen phosphorylase.

The structure of phosphorylase kinase holoenzyme at 9.9 angstroms resolution and location of the catalytic subunit and the substrate glycogen phosphorylase.

Phosphorylase kinase (PhK) coordinates hormonal and neuronal signals to initiate the breakdown of glycogen. The enzyme catalyzes the phosphorylation of inactive glycogen phosphorylase b (GPb), resulting in the formation of active glycogen phosphorylase a. We present a 9.9 angstroms resolution struct...

Volledige beschrijving

Bibliografische gegevens
Hoofdauteurs:	Vénien-Bryan, C, Jonic, S, Skamnaki, V, Brown, N, Bischler, N, Oikonomakos, N, Boisset, N, Johnson, L
Formaat:	Journal article
Taal:	English
Gepubliceerd in:	2009

Gelijkaardige items

Three-dimensional structure of phosphorylase kinase at 22 A resolution and its complex with glycogen phosphorylase b.
door: Vénien-Bryan, C, et al.
Gepubliceerd in: (2002)

INHIBITORS OF GLYCOGEN-PHOSPHORYLASE
door: Bichard, C, et al.
Gepubliceerd in: (1994)

Effects of commonly used cryoprotectants on glycogen phosphorylase activity and structure.
door: Tsitsanou, K, et al.
Gepubliceerd in: (1999)

GLUCOSE ANALOG INHIBITORS OF GLYCOGEN-PHOSPHORYLASE
door: Johnson, L, et al.
Gepubliceerd in: (1994)

Calcineurin B-like domains in the large regulatory alpha/beta subunits of phosphorylase kinase.
door: Carrière, C, et al.
Gepubliceerd in: (2008)

The binding of beta-glycerophosphate to glycogen phosphorylase b in the crystal.
door: Oikonomakos, N, et al.
Gepubliceerd in: (1989)

Glucopyranose spirohydantoins: Specific inhibitors of glycogen phosphorylase
door: delaFuente, C, et al.
Gepubliceerd in: (1997)

Phosphate-recognition sites in catalysis and control of glycogen phosphorylase b.
door: Johnson, L, et al.
Gepubliceerd in: (1987)

Catalysis in the crystal: synchrotron radiation studies with glycogen phosphorylase b.
door: Hajdu, J, et al.
Gepubliceerd in: (1987)

Stereospecific synthesis of spirohydantoins of beta-glucopyranose: Inhibitors of glycogen phosphorylase
door: Krulle, T, et al.
Gepubliceerd in: (1997)

Intersubunit communication in glycogen phosphorylase influences substrate recognition at the catalytic sites
door: Nahori Kamada, et al.
Gepubliceerd in: (2024-02-01)

Studies on the glycogen phosphorylase system
door: Busby, S
Gepubliceerd in: (1975)

Glucose analogue inhibitors of glycogen phosphorylase: the design of potential drugs for diabetes.
door: Martin, J, et al.
Gepubliceerd in: (1991)

Kinetic and crystallographic studies of glucopyranose spirohydantoin and glucopyranosylamine analogs inhibitors of glycogen phosphorylase.
door: Watson, K, et al.
Gepubliceerd in: (2005)

SPECIFIC-INHIBITION OF GLYCOGEN-PHOSPHORYLASE BY A SPIRODIKETOPIPERAZINE AT THE ANOMERIC POSITION OF GLUCOPYRANOSE
door: Krulle, T, et al.
Gepubliceerd in: (1995)

Structural changes in glycogen phosphorylase induced by phosphorylation.
door: Sprang, SR, et al.
Gepubliceerd in: (1988)

Cryocrystallographic and mechanistic studies on glycogen phosphorylase
door: Mitchell, E
Gepubliceerd in: (1994)

Substrate-cofactor interactions for glycogen phosphorylase b: a binding study in the crystal with heptenitol and heptulose 2-phosphate.
door: McLaughlin, P, et al.
Gepubliceerd in: (1984)

POTENT INHIBITION OF GLYCOGEN-PHOSPHORYLASE BY A SPIROHYDANTOIN OF GLUCOPYRANOSE - FIRST PYRANOSE ANALOGS OF HYDANTOCIDIN
door: Bichard, C, et al.
Gepubliceerd in: (1995)

On the promise of glycogen phosphorylase inhibition in acute inflammation
door: Aarooran Sivakumaran Durairaj, et al.
Gepubliceerd in: (2021-03-01)

Transcriptional regulation of rat brain glycogen phosphorylase
door: Hamprecht Bernd, et al.
Gepubliceerd in: (2007-03-01)

Optimization and Validation of an In Vitro Standardized Glycogen Phosphorylase Activity Assay
door: Sónia Rocha, et al.
Gepubliceerd in: (2021-07-01)

The role of glycogen phosphorylase in glycogen biogenesis in skeletal muscle after exercise
door: Abram Katz
Gepubliceerd in: (2023-03-01)

Uridine(5')diphospho(1)-alpha-D-glucose. A binding study to glycogen phosphorylase b in the crystal.
door: Oikonomakos, N, et al.
Gepubliceerd in: (1988)

Towards time-resolved diffraction studies with glycogen phosphorylase.
door: Duke, E, et al.
Gepubliceerd in: (1991)

Comparison of AMP and NADH binding to glycogen phosphorylase b.
door: Stura, E, et al.
Gepubliceerd in: (1983)

X-ray crystallographic studies of glycogen phosphorylase b
door: Wild, D, et al.
Gepubliceerd in: (1981)

TOWARDS TIME-RESOLVED DIFFRACTION STUDIES WITH GLYCOGEN-PHOSPHORYLASE
door: Duke, E, et al.
Gepubliceerd in: (1991)

TOWARDS TIME-RESOLVED DIFFRACTION STUDIES WITH GLYCOGEN-PHOSPHORYLASE
door: Duke, E, et al.
Gepubliceerd in: (1991)

Pyridoxal phosphate site in glycogen phosphorylase b: structure in native enzyme and in three derivatives with modified cofactors.
door: Oikonomakos, N, et al.
Gepubliceerd in: (1987)

Triazole carboxylic acids as anionic sugar mimics? Inhibition of glycogen phosphorylase by a D-glucotriazole carboxylate
door: Krulle, T, et al.
Gepubliceerd in: (1997)

Mitochondrial Redox Status Regulates Glycogen Metabolism via Glycogen Phosphorylase Activity
door: Ikko Sakamoto, et al.
Gepubliceerd in: (2024-11-01)

Physicochemical and Spectroscopic Characterization of Glycogen and Glycogen Phosphorylase <i>b</i> Complexes
door: Pandora Karakousi, et al.
Gepubliceerd in: (2024-07-01)

Muscle Glycogen Phosphorylase and Its Functional Partners in Health and Disease
door: Marta Migocka-Patrzałek, et al.
Gepubliceerd in: (2021-04-01)

N-acetyl-beta-D-glucopyranosylamine: a potent T-state inhibitor of glycogen phosphorylase. A comparison with alpha-D-glucose.
door: Oikonomakos, N, et al.
Gepubliceerd in: (1995)

The design of potential antidiabetic drugs: experimental investigation of a number of beta-D-glucose analogue inhibitors of glycogen phosphorylase.
door: Oikonomakos, N, et al.
Gepubliceerd in: (1994)

Inhibition of glycogen phosphorylase stimulates ventromedial hypothalamic nucleus AMP‐activated protein kinase
door: Hussain N. Alhamami, et al.
Gepubliceerd in: (2017-12-01)

Time-resolved structural studies on catalysis in the crystal with glycogen phosphorylase b.
door: Hajdu, J, et al.
Gepubliceerd in: (1986)

GLYCOGEN PHOSPHORYLASE-B - THE MOLECULAR ANATOMY OF A LARGE REGULATORY ENZYME
door: Sansom, M, et al.
Gepubliceerd in: (1985)

C-(β-D-Glucopyranosyl) heterocycles as potential glycogen phosphorylase inhibitors
door: Zsuzsa Hadady, et al.
Gepubliceerd in: (2004-03-01)