4-C-Me-DAB and 4-C-Me-LAB - enantiomeric alkyl-branched pyrrolidine iminosugars - are specific and potent α-glucosidase inhibitors; acetone as the sole protecting group.

The syntheses of 4-C-Me-DAB [1,4-dideoxy-1,4-imino-4-C-methyl-d-arabinitol] from l-erythronolactone and of 4-C-Me-LAB [from d-erythronolactone] require only a single acetonide protecting group. The effect of pH on the NMR spectra of 4-C-Me-DAB [pK(a) of the salt around 8.4] is discussed and illustra...

সম্পূর্ণ বিবরণ

গ্রন্থ-পঞ্জীর বিবরন
প্রধান লেখক: da Cruz, F, Newberry, S, Jenkinson, S, Wormald, M, Butters, T, Alonzi, D, Nakagawa, S, Becq, F, Norez, C, Nash, R, Kato, A, Fleet, G
বিন্যাস: Journal article
ভাষা:English
প্রকাশিত: 2011