SGLT2 Inhibition and cardiovascular events: why did EMPA-REG Outcomes surprise and what were the likely mechanisms?

While the modest reduction in the primary composite outcome of myocardial infarction, stroke or cardiovascular death in the EMPA-REG Outcomes trial was welcome, the 30-40% reductions in heart failure hospitalisation, cardiovascular and all-cause deaths on empagliflozin were highly impressive and une...

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Bibliographic Details
Main Authors: Sattar, N, McLaren, J, Kristensen, S, Preiss, D, McMurray, J
Format: Journal article
Published: Springer 2016