The acute light-induction of sleep is mediated by OPN4-based photoreception.
Sleep is regulated by both homeostatic and circadian mechanisms. The latter, termed 'process c', helps synchronize sleep-wake patterns to the appropriate time of the day. However, in the absence of a circadian clock, overall sleep-wake rhythmicity is preserved and remains synchronized to t...
| Hlavní autoři: | , , , |
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| Médium: | Journal article |
| Jazyk: | English |
| Vydáno: |
2008
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| _version_ | 1826306633034104832 |
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| author | Lupi, D Oster, H Thompson, S Foster, R |
| author_facet | Lupi, D Oster, H Thompson, S Foster, R |
| author_sort | Lupi, D |
| collection | OXFORD |
| description | Sleep is regulated by both homeostatic and circadian mechanisms. The latter, termed 'process c', helps synchronize sleep-wake patterns to the appropriate time of the day. However, in the absence of a circadian clock, overall sleep-wake rhythmicity is preserved and remains synchronized to the external light-dark cycle, indicating that there is an additional, clock-independent photic input to sleep. We found that the direct photic regulation of sleep in mice is predominantly mediated by melanopsin (OPN4)-based photoreception of photosensitive retinal ganglion cells (pRGCs). Moreover, OPN4-dependent sleep regulation was correlated with the activation of sleep-promoting neurons in the ventrolateral preoptic area and the superior colliculus. Collectively, our findings describe a previously unknown pathway in sleep regulation and identify the pRGC/OPN4 signaling system as a potentially new pharmacological target for the selective manipulation of sleep and arousal states. |
| first_indexed | 2024-03-07T06:50:55Z |
| format | Journal article |
| id | oxford-uuid:fc858c21-e8af-41d6-a22c-edabffdcc6fe |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:50:55Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | oxford-uuid:fc858c21-e8af-41d6-a22c-edabffdcc6fe2022-03-27T13:21:28ZThe acute light-induction of sleep is mediated by OPN4-based photoreception.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:fc858c21-e8af-41d6-a22c-edabffdcc6feEnglishSymplectic Elements at Oxford2008Lupi, DOster, HThompson, SFoster, RSleep is regulated by both homeostatic and circadian mechanisms. The latter, termed 'process c', helps synchronize sleep-wake patterns to the appropriate time of the day. However, in the absence of a circadian clock, overall sleep-wake rhythmicity is preserved and remains synchronized to the external light-dark cycle, indicating that there is an additional, clock-independent photic input to sleep. We found that the direct photic regulation of sleep in mice is predominantly mediated by melanopsin (OPN4)-based photoreception of photosensitive retinal ganglion cells (pRGCs). Moreover, OPN4-dependent sleep regulation was correlated with the activation of sleep-promoting neurons in the ventrolateral preoptic area and the superior colliculus. Collectively, our findings describe a previously unknown pathway in sleep regulation and identify the pRGC/OPN4 signaling system as a potentially new pharmacological target for the selective manipulation of sleep and arousal states. |
| spellingShingle | Lupi, D Oster, H Thompson, S Foster, R The acute light-induction of sleep is mediated by OPN4-based photoreception. |
| title | The acute light-induction of sleep is mediated by OPN4-based photoreception. |
| title_full | The acute light-induction of sleep is mediated by OPN4-based photoreception. |
| title_fullStr | The acute light-induction of sleep is mediated by OPN4-based photoreception. |
| title_full_unstemmed | The acute light-induction of sleep is mediated by OPN4-based photoreception. |
| title_short | The acute light-induction of sleep is mediated by OPN4-based photoreception. |
| title_sort | acute light induction of sleep is mediated by opn4 based photoreception |
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