Crystal structure of the RNA-dependent RNA polymerase from influenza C virus.

Negative-sense RNA viruses, such as influenza, encode large, multidomain RNA-dependent RNA polymerases that can both transcribe and replicate the viral RNA genome. In influenza virus, the polymerase (FluPol) is composed of three polypeptides: PB1, PB2 and PA/P3. PB1 houses the polymerase active site...

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Bibliographic Details
Main Authors: Hengrung, N, Omari, K, Martin, I, Vreede, F, Cusack, S, Rambo, R, Vonrhein, C, Bricogne, G, Stuart, D, Grimes, J, Fodor, E
Format: Journal article
Language:English
Published: Nature Publishing Group 2015