Purine nucleotide metabolism regulates expression of the human immune ligand MICA

Expression of the cell-surface glycoprotein MHC class I polypeptide-related sequence A (MICA) is induced in dangerous, abnormal, or “stressed” cells, including cancer cells, virus-infected cells, and rapidly proliferating cells. MICA is recognized by the activating immune cell receptor natural kille...

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Bibliographic Details
Main Authors: McCarthy, MT, Moncayo, G, Hiron, TK, Jakobsen, NA, Vali, A, Soga, T, Adam, J, O'Callaghan, CA
Format: Journal article
Language:English
Published: American Society for Biochemistry and Molecular Biology 2017