A general copper-mediated nucleophilic 18F fluorination of arenes

Molecules labeled with fluorine-18 are used as radiotracers for positron emission tomography. An important challenge is the labeling of arenes not amenable to aromatic nucleophilic substitution (SNAr) with [ 18F]F-. In the ideal case, the 18F fluorination of these substrates would be performed throu...

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Main Authors: Tredwell, M, Preshlock, S, Taylor, N, Gruber, S, Huiban, M, Passchier, J, Mercier, J, Génicot, C, Gouverneur, V
格式: Journal article
出版: 2014