Hinges, swivels and switches: the role of prolines in signalling via transmembrane alpha-helices.
Extracellular signals are transduced across membranes via conformational changes in the transmembrane domains (TMs) of ion channels and G-protein-coupled receptors (GPCRs). Experimental and simulation studies indicate that such conformational switches in transmembrane (alpha-helices can be generated...
| Glavni autori: | , |
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| Format: | Journal article |
| Jezik: | English |
| Izdano: |
2000
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