Lysosomal dysfunction promotes cleavage and neurotoxicity of tau in vivo.

Lysosomal dysfunction promotes cleavage and neurotoxicity of tau in vivo.

Toon andere (1) versies

Expansion of the lysosomal system, including cathepsin D upregulation, is an early and prominent finding in Alzheimer's disease brain. Cell culture studies, however, have provided differing perspectives on the lysosomal connection to Alzheimer's disease, including both protective and detri...

Volledige beschrijving

Bibliografische gegevens
Hoofdauteurs:	Khurana, V, Elson-Schwab, I, Fulga, T, Sharp, K, Loewen, C, Mulkearns, E, Tyynelä, J, Scherzer, C, Feany, M
Formaat:	Journal article
Taal:	English
Gepubliceerd in:	2010

Gelijkaardige items

Lysosomal dysfunction promotes cleavage and neurotoxicity of tau in vivo
door: Khurana, V, et al.
Gepubliceerd in: (2010)

Lysosomal dysfunction promotes cleavage and neurotoxicity of tau in vivo.
door: Vikram Khurana, et al.
Gepubliceerd in: (2010-07-01)

The unfolded protein response protects from tau neurotoxicity in vivo.
door: Carin A Loewen, et al.
Gepubliceerd in: (2010-09-01)

Tau phosphorylation sites work in concert to promote neurotoxicity in vivo.
door: Steinhilb, M, et al.
Gepubliceerd in: (2007)

Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo.
door: Fulga, T, et al.
Gepubliceerd in: (2007)

Aggregated alpha-synuclein mediates dopaminergic neurotoxicity in vivo.
door: Periquet, M, et al.
Gepubliceerd in: (2007)

Oxidative stress mediates tau-induced neurodegeneration in Drosophila.
door: Dias-Santagata, D, et al.
Gepubliceerd in: (2007)

The role of TFEB-mediated autophagy-lysosome dysfunction in manganese neurotoxicity
door: Jiaqiao Lu, et al.
Gepubliceerd in: (2024-01-01)

Tau Oligomers Neurotoxicity
door: Grazyna Niewiadomska, et al.
Gepubliceerd in: (2021-01-01)

Activity-dependent tau cleavage by caspase-3 promotes neuronal dysfunction and synaptotoxicity
door: Carli K. Opland, et al.
Gepubliceerd in: (2023-06-01)

Senseless makes sense for spinocerebellar ataxia-1.
door: Khurana, V, et al.
Gepubliceerd in: (2005)

Amphiphysin I cleavage by asparagine endopeptidase leads to tau hyperphosphorylation and synaptic dysfunction
door: Xingyu Zhang, et al.
Gepubliceerd in: (2021-05-01)

Oligomerization of Lrrk controls actin severing and α-synuclein neurotoxicity in vivo
door: Souvarish Sarkar, et al.
Gepubliceerd in: (2021-05-01)

Acrylamide‐induced autophagy‐lysosomal pathway dysfunction contributing to neurotoxicity through targeting transcription factor EB
door: Liuqing Yang, et al.
Gepubliceerd in: (2023-09-01)

TDP-43 promotes tau accumulation and selective neurotoxicity in bigenic Caenorhabditis elegans
door: Caitlin S. Latimer, et al.
Gepubliceerd in: (2022-04-01)

Hyperphosphorylation and cleavage at D421 enhance tau secretion.
door: Vanessa Plouffe, et al.
Gepubliceerd in: (2012-01-01)

VPS35 dysfunction impairs lysosomal degradation of α-synuclein and exacerbates neurotoxicity in a Drosophila model of Parkinson's disease
door: Emiko Miura, et al.
Gepubliceerd in: (2014-11-01)

Tau accumulation in degradative organelles is associated to lysosomal stress
door: Ester Piovesana, et al.
Gepubliceerd in: (2023-10-01)

A neuroprotective role for the DNA damage checkpoint in tauopathy
door: Khurana, V, et al.
Gepubliceerd in: (2012)

Caspase-9 Activation and Caspase Cleavage of tau in the Alzheimer's Disease Brain
door: Troy T. Rohn, et al.
Gepubliceerd in: (2002-11-01)

OPTN attenuates the neurotoxicity of abnormal Tau protein by restoring autophagy
door: Yin Xu, et al.
Gepubliceerd in: (2022-06-01)

Tau as a mediator of neurotoxicity associated to cerebral amyloid angiopathy
door: Yingjian You, et al.
Gepubliceerd in: (2019-02-01)

A neuroprotective role for the DNA damage checkpoint in tauopathy.
door: Khurana, V, et al.
Gepubliceerd in: (2012)

Proapoptotic Effects of Tau Cleavage Product Generated by Caspase-3
door: Chul-Woong Chung, et al.
Gepubliceerd in: (2001-02-01)

Age-Related Lysosomal Dysfunctions
door: Lena Guerrero-Navarro, et al.
Gepubliceerd in: (2022-06-01)

Lysosomal dysfunction in diabetic cardiomyopathy
door: Satoru Kobayashi, et al.
Gepubliceerd in: (2023-01-01)

Functional screening of lysosomal storage disorder genes identifies modifiers of alpha-synuclein neurotoxicity.
door: Meigen Yu, et al.
Gepubliceerd in: (2023-05-01)

Autophagic and endo-lysosomal dysfunction in neurodegenerative disease
door: Bilal R. Malik, et al.
Gepubliceerd in: (2019-11-01)

Selective clearance of aberrant tau proteins and rescue of neurotoxicity by transcription factor EB
door: Vinicia A Polito, et al.
Gepubliceerd in: (2014-07-01)

Cleavage of Hsp70.1 causes lysosomal cell death under stress conditions
door: Tetsumori Yamashima, et al.
Gepubliceerd in: (2024-05-01)

Unconventional secretion of tau by VAMP8 impacts its intra- and extracellular cleavage
door: Julie Pilliod, et al.
Gepubliceerd in: (2022-10-01)

Delta-secretase cleavage of Tau mediates its pathology and propagation in Alzheimer’s disease
door: Seong Su Kang, et al.
Gepubliceerd in: (2020-08-01)

Lysosomal-endolysomal dysfunction and neurodegenerative diseases
door: Matthew E. Gegg, et al.
Gepubliceerd in: (2022-10-01)

Mitochondrial Dysfunction in Lysosomal Storage Disorders
door: Mario de la Mata, et al.
Gepubliceerd in: (2016-10-01)

The cell biology of disease: lysosomal storage disorders: the cellular impact of lysosomal dysfunction.
door: Platt, F, et al.
Gepubliceerd in: (2012)

The SARS-CoV-2 main protease induces neurotoxic TDP-43 cleavage and aggregates
door: Jiaxin Yang, et al.
Gepubliceerd in: (2023-03-01)

The inhibition of TRPML1/TFEB leads to lysosomal biogenesis disorder, contributes to developmental fluoride neurotoxicity
door: Jingjing Zhang, et al.
Gepubliceerd in: (2023-01-01)

DYRK1A antagonists rescue degeneration and behavioural deficits of in vivo models based on amyloid-β, Tau and DYRK1A neurotoxicity
door: Bangfu Zhu, et al.
Gepubliceerd in: (2022-09-01)

Self‐Aggregating Tau Fragments Recapitulate Pathologic Phenotypes and Neurotoxicity of Alzheimer's Disease in Mice
door: Ly Thi Huong Luu Le, et al.
Gepubliceerd in: (2023-10-01)

Dual Vulnerability of Tau to Calpains and Caspase-3 Proteolysis Under Neurotoxic and Neurodegenerative Conditions
door: Ming Cheng Liu, et al.
Gepubliceerd in: (2010-11-01)