Lysosomal dysfunction promotes cleavage and neurotoxicity of tau in vivo.

Lysosomal dysfunction promotes cleavage and neurotoxicity of tau in vivo.

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Expansion of the lysosomal system, including cathepsin D upregulation, is an early and prominent finding in Alzheimer's disease brain. Cell culture studies, however, have provided differing perspectives on the lysosomal connection to Alzheimer's disease, including both protective and detri...

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Библиографические подробности
Главные авторы:	Khurana, V, Elson-Schwab, I, Fulga, T, Sharp, K, Loewen, C, Mulkearns, E, Tyynelä, J, Scherzer, C, Feany, M
Формат:	Journal article
Язык:	English
Опубликовано:	2010

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