CHIP-mediated degradation and DNA damage-dependent stabilization regulate base excision repair proteins.

CHIP-mediated degradation and DNA damage-dependent stabilization regulate base excision repair proteins.

Base excision repair (BER) is the major pathway for processing of simple lesions in DNA, including single-strand breaks, base damage, and base loss. The scaffold protein XRCC1, DNA polymerase beta, and DNA ligase IIIalpha play pivotal roles in BER. Although all these enzymes are essential for develo...

Bibliográfalaš dieđut
Váldodahkkit:	Parsons, J, Tait, P, Finch, D, Dianova, I, Allinson, S, Dianov, G
Materiálatiipa:	Journal article
Giella:	English
Almmustuhtton:	2008

Geahča maid

DNA polymerase beta promotes recruitment of DNA ligase III alpha-XRCC1 to sites of base excision repair.
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XRCC1-DNA polymerase beta interaction is required for efficient base excision repair.
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XRCC1 phosphorylation by CK2 is required for its stability and efficient DNA repair.
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Repair of abasic sites in DNA.
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Poly(ADP-ribose) polymerase-1 protects excessive DNA strand breaks from deterioration during repair in human cell extracts.
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Monitoring base excision repair proteins on damaged DNA using human cell extracts.
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Ubiquitin ligase ARF-BP1/Mule modulates base excision repair.
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Co-ordination of base excision repair and genome stability.
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APE1-dependent repair of DNA single-strand breaks containing 3'-end 8-oxoguanine.
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USP47 is a deubiquitylating enzyme that regulates base excision repair by controlling steady-state levels of DNA polymerase β.
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Almmustuhtton: (2011)

Orchestration of base excision repair by controlling the rates of enzymatic activities.
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End-damage-specific proteins facilitate recruitment or stability of X-ray cross-complementing protein 1 at the sites of DNA single-strand break repair.
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DNA base damage recognition and processing
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USP7/HAUSP stimulates repair of oxidative DNA lesions.
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DNA repair fidelity of base excision repair pathways in human cell extracts.
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In vitro base excision repair using mammalian cell extracts.
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Poly(ADP-ribose) polymerase-1 modulates DNA repair capacity and prevents formation of DNA double strand breaks.
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ATM-Dependent Downregulation of USP7/HAUSP by PPM1G Activates p53 Response to DNA Damage
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ATM-dependent downregulation of USP7/HAUSP by PPM1G activates p53 response to DNA damage.
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USP7S-dependent inactivation of Mule regulates DNA damage signalling and repair.
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DNA base excision repair: the Achilles' heel of tumour cells and their microenvironment?
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Exchangeability of mammalian DNA ligases between base excision repair pathways.
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Ubiquitin ligase UBR3 regulates cellular levels of the essential DNA repair protein APE1 and is required for genome stability.
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Cells deficient in the base excision repair protein, DNA polymerase beta, are hypersensitive to oxaliplatin chemotherapy.
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Monitoring base excision repair by in vitro assays.
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Base excision repair targets for cancer therapy.
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Isolation of a small molecule inhibitor of DNA base excision repair.
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CK2 phosphorylation of XRCC1 facilitates dissociation from DNA and single-strand break formation during base excision repair.
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Mammalian base excision repair: the forgotten archangel.
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Targeting base excision repair to improve cancer therapies.
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DNA Damage and Base Excision Repair in Mitochondria and Their Role in Aging
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Mechanism and regulation of DNA damage recognition in nucleotide excision repair
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The emerging role of Mule and ARF in the regulation of base excision repair.
Dahkki: Khoronenkova, S, et al.
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The emerging role of Mule and ARF in the regulation of base excision repair
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ATR- and ATM-Mediated DNA Damage Response Is Dependent on Excision Repair Assembly during G1 but Not in S Phase of Cell Cycle.
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Regulation of DNA repair by ubiquitylation.
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DNA polymerase delta-dependent repair of DNA single strand breaks containing 3'-end proximal lesions.
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Co-ordination of DNA single strand break repair.
Dahkki: Dianov, G, et al.
Almmustuhtton: (2007)

Base excision repair fidelity in normal and cancer cells.
Dahkki: Chan, K, et al.
Almmustuhtton: (2006)

Base excision repair of radiation-induced DNA damage in mammalian cells
Dahkki: Cooper, S, et al.
Almmustuhtton: (2013)