Pharmacokinetics of quinine, chloroquine and amodiaquine. Clinical implications.
Malaria is associated with a reduction in the systemic clearance and apparent volume of distribution of the cinchona alkaloids; this reduction is proportional to the disease severity. There is increased plasma protein binding, predominantly to alpha 1-acid glycoprotein, and elimination half-lives (i...
| Glavni autori: | , |
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| Format: | Journal article |
| Jezik: | English |
| Izdano: |
1996
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