Decreased striatal dopamine in group II metabotropic glutamate receptor (mGlu2/mGlu3) double knockout mice.

BACKGROUND: Group II metabotropic glutamate receptors (mGlu2 and mGlu3, encoded by Grm2 and Grm3) have been the focus of attention as treatment targets for a number of psychiatric conditions. Double knockout mice lacking mGlu2 and mGlu3 (mGlu2/3-/-) show a subtle behavioural phenotype, being hypoact...

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Κύριοι συγγραφείς: Lane, T, Boerner, T, Bannerman, D, Kew, J, Tunbridge, E, Sharp, T, Harrison, P
Μορφή: Journal article
Γλώσσα:English
Έκδοση: 2013