Human aneuploid cells depend on the RAF/MEK/ERK pathway for overcoming increased DNA damage

Human aneuploid cells depend on the RAF/MEK/ERK pathway for overcoming increased DNA damage

Aneuploidy is a hallmark of human cancer, yet the molecular mechanisms to cope with aneuploidy-induced cellular stresses remain largely unknown. Here, we induce chromosome mis-segregation in non-transformed RPE1-hTERT cells and derive multiple stable clones with various degrees of aneuploidy. We per...

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Hlavní autoři: Zerbib, J, Ippolito, MR, Eliezer, Y, De Feudis, G, Reuveni, E, Savir Kadmon, A, Martin, S, Viganò, S, Leor, G, Berstler, J, Muenzner, J, Mülleder, M, Campagnolo, EM, Shulman, ED, Chang, T, Rubolino, C, Laue, K, Cohen-Sharir, Y, Scorzoni, S, Taglietti, S, Ratti, A, Stossel, C, Golan, T, Nicassio, F, Ralser, M
Médium: Journal article
Jazyk:English
Vydáno: Nature Research 2024

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