Targeting the mevalonate pathway for pharmacological intervention
Farnesyl pyrophosphate synthase (FPPS) is a key branch point enzyme in the mevalonate pathway and the main molecular target of nitrogen-containing bisphosphonates (N-BPs), potent inhibitors of osteoclastic activity and the leading drug of choice for conditions characterized by excessive bone resorpt...
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| Формат: | Диссертация |
| Язык: | English |
| Опубликовано: |
2011
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