Evaluation of an In Silico Cardiac Safety Assay: Using Ion Channel Screening Data to Predict QT Interval Changes in the Rabbit Ventricular Wedge
<h3>Introduction</h3> Drugs that prolong the QT interval on the electrocardiogram present a major safety concern for pharmaceutical companies and regulatory agencies. Despite a range of assays performed to assess compound effects on the QT interval, QTprolongation remains a major cause o...
Main Authors: | Beattie, K, Luscombe, C, Williams, G, Munoz−Muriedas, J, Gavaghan, D, Cui, Y, Mirams, G |
---|---|
Format: | Journal article |
Published: |
2013
|
Similar Items
-
Evaluation of an in silico cardiac safety assay: Using ion channel screening data to predict QT interval changes in the rabbit ventricular wedge
by: Beattie, K, et al.
Published: (2013) -
Evaluation of computational modelling as a preclinical proarrhythmic safety assay
by: Mirams, G, et al.
Published: (2013) -
L−TYPE CALCIUM CHANNELS AND CALCIUM REGULATION IN VENTRICULAR MYOCYTES: IN SILICO STUDIES
by: Sher, A, et al.
Published: (2009) -
THE L-TYPE CALCIUM CHANNELS AND CALCIUM REGULATION IN VENTRICULAR MYOCYTES: IN SILICO STUDIES
by: Sher, A, et al.
Published: (2009) -
Relationship between QT interval and ventricular electrical axis: A new suggestion for Lead selection in QT interval measurement
by: "Moradman S, et al.
Published: (2000-09-01)