Growth-induced buckling of an epithelial layer.

We use a proof-of-concept experiment and two mathematical models to explore growth-induced tissue buckling, as may occur in colorectal crypt formation. Our experiment reveals how growth of a cultured epithelial monolayer on a thin flexible substrate can cause out-of-plane substrate deflections. We d...

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Bibliographic Details
Main Authors: Nelson, MR, Howard, D, Jensen, O, King, JR, Rose, F, Waters, S
Format: Journal article
Language:English
Published: 2011