Growth-induced buckling of an epithelial layer.
We use a proof-of-concept experiment and two mathematical models to explore growth-induced tissue buckling, as may occur in colorectal crypt formation. Our experiment reveals how growth of a cultured epithelial monolayer on a thin flexible substrate can cause out-of-plane substrate deflections. We d...
Main Authors: | Nelson, MR, Howard, D, Jensen, O, King, JR, Rose, F, Waters, S |
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Format: | Journal article |
Language: | English |
Published: |
2011
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