Structural basis for the improved drug resistance profile of new generation benzophenone non-nucleoside HIV-1 reverse transcriptase inhibitors.

Owing to the emergence of resistant virus, next generation non-nucleoside HIV reverse transcriptase inhibitors (NNRTIs) with improved drug resistance profiles have been developed to treat HIV infection. Crystal structures of HIV-1 RT complexed with benzophenones optimized for inhibition of HIV mutan...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron: Ren, J, Chamberlain, P, Stamp, A, Short, SA, Weaver, K, Romines, K, Hazen, R, Freeman, A, Ferris, R, Andrews, C, Boone, L, Chan, J, Stammers, D
Fformat: Journal article
Iaith:English
Cyhoeddwyd: 2008