Ezh2 and Runx1 mutations collaborate to initiate lympho-myeloid leukemia in early thymic progenitors

Ezh2 and Runx1 mutations collaborate to initiate lympho-myeloid leukemia in early thymic progenitors

Lympho-myeloid restricted early thymic progenitors (ETPs) are postulated to be the cell of origin for ETP leukemias, a therapy-resistant leukemia associated with frequent co-occurrence of EZH2 and RUNX1 inactivating mutations, and constitutively activating signaling pathway mutations. In a mouse mod...

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Bibliographic Details
Main Authors: Booth, CAG, Barkas, N, Neo, WH, Boukarabila, H, Soilleux, EJ, Giotopoulos, G, Farnoud, N, Giustacchini, A, Ashley, N, Carrelha, J, Jamieson, L, Atkinson, D, Bouriez-Jones, T, Prinjha, RK, Milne, TA, Teachey, DT, Papaemmanuil, E, Huntly, BJP, Jacobsen, SEW, Mead, AJ
Format: Journal article
Language:English
Published: Elsevier 2018

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