Single-cell transcriptomics identifies a WNT7A-FZD5 signaling axis that maintains fallopian tube stem cells in patient-derived organoids

The study of fallopian tube (FT) function in health and disease has been hampered by limited knowledge of FT stem cells and lack of in vitro models of stem cell renewal and differentiation. Using optimized organoid culture conditions to address these limitations, we find that FT stem cell renewal is...

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Bibliographic Details
Main Authors: Alsaadi, A, Artibani, M, Hu, Z, Wietek, N, Morotti, M, Santana Gonzalez, L, Soleymani Majd, H, Ahmed, A
Format: Journal article
Language:English
Published: Cell Press 2023