High level of PD-1 expression on hepatitis C virus (HCV)-specific CD8+ and CD4+ T cells during acute HCV infection, irrespective of clinical outcome.

High level of PD-1 expression on hepatitis C virus (HCV)-specific CD8+ and CD4+ T cells during acute HCV infection, irrespective of clinical outcome.

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We monitored expression of PD-1 (a mediator of T-cell exhaustion and viral persistence) on hepatitis C virus (HCV)-specific CD8(+) and CD4(+) T cells from blood and liver during acute and chronic infections and after the resolved infection stage. PD-1 expression on HCV-specific T cells was high earl...

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Bibliographic Details
Main Authors: Kasprowicz, V, Schulze Zur Wiesch, J, Kuntzen, T, Nolan, B, Longworth, S, Berical, A, Blum, J, McMahon, C, Reyor, L, Elias, N, Kwok, W, McGovern, BG, Freeman, G, Chung, RT, Klenerman, P, Lewis-Ximenez, L, Walker, B, Allen, T, Kim, A, Lauer, G
Format: Journal article
Language:English
Published: 2008

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