High level of PD-1 expression on hepatitis C virus (HCV)-specific CD8+ and CD4+ T cells during acute HCV infection, irrespective of clinical outcome.

High level of PD-1 expression on hepatitis C virus (HCV)-specific CD8+ and CD4+ T cells during acute HCV infection, irrespective of clinical outcome.

Taispeáin leaganacha eile (1)

We monitored expression of PD-1 (a mediator of T-cell exhaustion and viral persistence) on hepatitis C virus (HCV)-specific CD8(+) and CD4(+) T cells from blood and liver during acute and chronic infections and after the resolved infection stage. PD-1 expression on HCV-specific T cells was high earl...

Cur síos iomlán

Sonraí bibleagrafaíochta
Príomhchruthaitheoirí: Kasprowicz, V, Schulze Zur Wiesch, J, Kuntzen, T, Nolan, B, Longworth, S, Berical, A, Blum, J, McMahon, C, Reyor, L, Elias, N, Kwok, W, McGovern, BG, Freeman, G, Chung, RT, Klenerman, P, Lewis-Ximenez, L, Walker, B, Allen, T, Kim, A, Lauer, G
Formáid: Journal article
Teanga:English
Foilsithe / Cruthaithe: 2008
Cur síos
Achoimre:We monitored expression of PD-1 (a mediator of T-cell exhaustion and viral persistence) on hepatitis C virus (HCV)-specific CD8(+) and CD4(+) T cells from blood and liver during acute and chronic infections and after the resolved infection stage. PD-1 expression on HCV-specific T cells was high early in acute infection irrespective of clinical outcome, and most cells continued to express PD-1 in resolved and chronic stages of infection; intrahepatic expression levels were especially high. Our results suggest that an analysis of PD-1 expression alone is not sufficient to predict infection outcome or to determine T-cell functionality in HCV infection.

Míreanna comhchosúla