High level of PD-1 expression on hepatitis C virus (HCV)-specific CD8+ and CD4+ T cells during acute HCV infection, irrespective of clinical outcome.
We monitored expression of PD-1 (a mediator of T-cell exhaustion and viral persistence) on hepatitis C virus (HCV)-specific CD8(+) and CD4(+) T cells from blood and liver during acute and chronic infections and after the resolved infection stage. PD-1 expression on HCV-specific T cells was high earl...
| Main Authors: | , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2008
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| _version_ | 1826307177886777344 |
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| author | Kasprowicz, V Schulze Zur Wiesch, J Kuntzen, T Nolan, B Longworth, S Berical, A Blum, J McMahon, C Reyor, L Elias, N Kwok, W McGovern, BG Freeman, G Chung, RT Klenerman, P Lewis-Ximenez, L Walker, B Allen, T Kim, A Lauer, G |
| author_facet | Kasprowicz, V Schulze Zur Wiesch, J Kuntzen, T Nolan, B Longworth, S Berical, A Blum, J McMahon, C Reyor, L Elias, N Kwok, W McGovern, BG Freeman, G Chung, RT Klenerman, P Lewis-Ximenez, L Walker, B Allen, T Kim, A Lauer, G |
| author_sort | Kasprowicz, V |
| collection | OXFORD |
| description | We monitored expression of PD-1 (a mediator of T-cell exhaustion and viral persistence) on hepatitis C virus (HCV)-specific CD8(+) and CD4(+) T cells from blood and liver during acute and chronic infections and after the resolved infection stage. PD-1 expression on HCV-specific T cells was high early in acute infection irrespective of clinical outcome, and most cells continued to express PD-1 in resolved and chronic stages of infection; intrahepatic expression levels were especially high. Our results suggest that an analysis of PD-1 expression alone is not sufficient to predict infection outcome or to determine T-cell functionality in HCV infection. |
| first_indexed | 2024-03-07T06:59:01Z |
| format | Journal article |
| id | oxford-uuid:ff19e3ac-cb6e-4e43-b9ee-2f3fecc4aae1 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T06:59:01Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | oxford-uuid:ff19e3ac-cb6e-4e43-b9ee-2f3fecc4aae12022-03-27T13:42:05ZHigh level of PD-1 expression on hepatitis C virus (HCV)-specific CD8+ and CD4+ T cells during acute HCV infection, irrespective of clinical outcome.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:ff19e3ac-cb6e-4e43-b9ee-2f3fecc4aae1EnglishSymplectic Elements at Oxford2008Kasprowicz, VSchulze Zur Wiesch, JKuntzen, TNolan, BLongworth, SBerical, ABlum, JMcMahon, CReyor, LElias, NKwok, WMcGovern, BGFreeman, GChung, RTKlenerman, PLewis-Ximenez, LWalker, BAllen, TKim, ALauer, GWe monitored expression of PD-1 (a mediator of T-cell exhaustion and viral persistence) on hepatitis C virus (HCV)-specific CD8(+) and CD4(+) T cells from blood and liver during acute and chronic infections and after the resolved infection stage. PD-1 expression on HCV-specific T cells was high early in acute infection irrespective of clinical outcome, and most cells continued to express PD-1 in resolved and chronic stages of infection; intrahepatic expression levels were especially high. Our results suggest that an analysis of PD-1 expression alone is not sufficient to predict infection outcome or to determine T-cell functionality in HCV infection. |
| spellingShingle | Kasprowicz, V Schulze Zur Wiesch, J Kuntzen, T Nolan, B Longworth, S Berical, A Blum, J McMahon, C Reyor, L Elias, N Kwok, W McGovern, BG Freeman, G Chung, RT Klenerman, P Lewis-Ximenez, L Walker, B Allen, T Kim, A Lauer, G High level of PD-1 expression on hepatitis C virus (HCV)-specific CD8+ and CD4+ T cells during acute HCV infection, irrespective of clinical outcome. |
| title | High level of PD-1 expression on hepatitis C virus (HCV)-specific CD8+ and CD4+ T cells during acute HCV infection, irrespective of clinical outcome. |
| title_full | High level of PD-1 expression on hepatitis C virus (HCV)-specific CD8+ and CD4+ T cells during acute HCV infection, irrespective of clinical outcome. |
| title_fullStr | High level of PD-1 expression on hepatitis C virus (HCV)-specific CD8+ and CD4+ T cells during acute HCV infection, irrespective of clinical outcome. |
| title_full_unstemmed | High level of PD-1 expression on hepatitis C virus (HCV)-specific CD8+ and CD4+ T cells during acute HCV infection, irrespective of clinical outcome. |
| title_short | High level of PD-1 expression on hepatitis C virus (HCV)-specific CD8+ and CD4+ T cells during acute HCV infection, irrespective of clinical outcome. |
| title_sort | high level of pd 1 expression on hepatitis c virus hcv specific cd8 and cd4 t cells during acute hcv infection irrespective of clinical outcome |
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