Structure of the dual mode Wnt regulator Kremen1 and insight into ternary complex formation with LRP6 and Dickkopf
Kremen (Krm) 1 and 2 have been identified as co-receptors for Dickkopf (Dkk) proteins, hallmark secreted antagonists of canonical Wnt signalling. We present here three crystal structures of the ectodomain of human Kremen1 (KRM1ECD) at resolutions between 1.9 and 3.2 Å. Krm1ECD emerges as a rigid mol...
| Main Authors: | , , , |
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| Format: | Journal article |
| Published: |
Cell Press
2016
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