NPC1 deficiency in mice is associated with fetal growth restriction, neonatal lethality and abnormal lung pathology

The rare lysosomal storage disorder Niemann-Pick disease type C1 (NPC1) arises from mutation of NPC1, which encodes a lysosomal transmembrane protein essential for normal transport and trafficking of cholesterol and sphingolipids. NPC1 is highly heterogeneous in both clinical phenotypes and age of o...

詳細記述

書誌詳細
主要な著者: Rodriguez-Gil, J, Watkins-Chow, D, Baxter, L, Yokoyama, T, Zerfas, P, Starost, M, Gahl, W, Malicdan, M, Porter, F, Platt, F, Paven, W
フォーマット: Journal article
出版事項: MDPI 2019