Synthesis of the taxol core via catalytic asymmetric 1,4-addition of an Alkylzirconium Nucleophile

Synthesis of the taxol core via catalytic asymmetric 1,4-addition of an Alkylzirconium Nucleophile

The Taxol core was prepared in five steps via a key copper-catalyzed asymmetric conjugate addition trapping sequence. The use of a bromodiene-derived alkylzirconium nucleophile followed by trapping with POCl3/DMF gave a highly functionalized intermediate featuring a quaternary center in 69% yield wi...

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Bibliografische gegevens
Hoofdauteurs:	Wang, JYJ, Fletcher, S
Formaat:	Journal article
Taal:	English
Gepubliceerd in:	American Chemical Society 2020

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