Target gene selectivity of hypoxia-inducible factor-alpha in renal cancer cells is conveyed by post-DNA-binding mechanisms.

Inactivation of the von Hippel-Lindau tumour suppressor in renal cell carcinoma (RCC) leads to failure of proteolytic regulation of the alpha subunits of hypoxia-inducible factor (HIF), constitutive upregulation of the HIF complex, and overexpression of HIF target genes. However, recent studies have...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron: Lau, K, Tian, Y, Raval, R, Ratcliffe, P, Pugh, C
Fformat: Journal article
Iaith:English
Cyhoeddwyd: 2007