Target gene selectivity of hypoxia-inducible factor-alpha in renal cancer cells is conveyed by post-DNA-binding mechanisms.

Inactivation of the von Hippel-Lindau tumour suppressor in renal cell carcinoma (RCC) leads to failure of proteolytic regulation of the alpha subunits of hypoxia-inducible factor (HIF), constitutive upregulation of the HIF complex, and overexpression of HIF target genes. However, recent studies have...

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Hlavní autoři: Lau, K, Tian, Y, Raval, R, Ratcliffe, P, Pugh, C
Médium: Journal article
Jazyk:English
Vydáno: 2007