Different chemically substituted chitooligosaccharides inhibit beta-secretase activity
Chitooligosaccharide or COS is a kind of oligosaccharide that is an integral part of the nervous system. COS is synthesized by chemical substitution and derived AE-COS, DEAE-COS and DMAE-COS that are being shown on IC(50) value. AE-COS and DMAE-COS exhibited four fold less inhibition than DEAE-COS....
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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2011
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| Online Access: | http://eprints.um.edu.my/10716/1/Different_chemically_substituted_chitooligosaccharides_inhibit_beta-secretase_activity.PDF |
| _version_ | 1825719902840815616 |
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| author | Ahmed, A.B.A. Yoon, N.Y. Taha, R.M. Kim, S.K. |
| author_facet | Ahmed, A.B.A. Yoon, N.Y. Taha, R.M. Kim, S.K. |
| author_sort | Ahmed, A.B.A. |
| collection | UM |
| description | Chitooligosaccharide or COS is a kind of oligosaccharide that is an integral part of the nervous system. COS is synthesized by chemical substitution and derived AE-COS, DEAE-COS and DMAE-COS that are being shown on IC(50) value. AE-COS and DMAE-COS exhibited four fold less inhibition than DEAE-COS. In addition, non-competitive inhibitor was identified via a Dixon plot and the Ki inhibition constant (100 mu g/mL). We declared, chemical substitution of COS is a water soluble human safe BACE-1 inhibitor. |
| first_indexed | 2024-03-06T05:26:49Z |
| format | Article |
| id | um.eprints-10716 |
| institution | Universiti Malaya |
| language | English |
| last_indexed | 2024-03-06T05:26:49Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | um.eprints-107162014-08-06T00:28:56Z http://eprints.um.edu.my/10716/ Different chemically substituted chitooligosaccharides inhibit beta-secretase activity Ahmed, A.B.A. Yoon, N.Y. Taha, R.M. Kim, S.K. QH301 Biology Chitooligosaccharide or COS is a kind of oligosaccharide that is an integral part of the nervous system. COS is synthesized by chemical substitution and derived AE-COS, DEAE-COS and DMAE-COS that are being shown on IC(50) value. AE-COS and DMAE-COS exhibited four fold less inhibition than DEAE-COS. In addition, non-competitive inhibitor was identified via a Dixon plot and the Ki inhibition constant (100 mu g/mL). We declared, chemical substitution of COS is a water soluble human safe BACE-1 inhibitor. 2011 Article PeerReviewed application/pdf en http://eprints.um.edu.my/10716/1/Different_chemically_substituted_chitooligosaccharides_inhibit_beta-secretase_activity.PDF Ahmed, A.B.A. and Yoon, N.Y. and Taha, R.M. and Kim, S.K. (2011) Different chemically substituted chitooligosaccharides inhibit beta-secretase activity. Chimica Oggi-Chemistry Today, 29 (5). pp. 77-79. ISSN 0392-839X, |
| spellingShingle | QH301 Biology Ahmed, A.B.A. Yoon, N.Y. Taha, R.M. Kim, S.K. Different chemically substituted chitooligosaccharides inhibit beta-secretase activity |
| title | Different chemically substituted chitooligosaccharides inhibit beta-secretase activity |
| title_full | Different chemically substituted chitooligosaccharides inhibit beta-secretase activity |
| title_fullStr | Different chemically substituted chitooligosaccharides inhibit beta-secretase activity |
| title_full_unstemmed | Different chemically substituted chitooligosaccharides inhibit beta-secretase activity |
| title_short | Different chemically substituted chitooligosaccharides inhibit beta-secretase activity |
| title_sort | different chemically substituted chitooligosaccharides inhibit beta secretase activity |
| topic | QH301 Biology |
| url | http://eprints.um.edu.my/10716/1/Different_chemically_substituted_chitooligosaccharides_inhibit_beta-secretase_activity.PDF |
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