Over-expression of Runx1 transcription factor impairs the development of thymocytes from the double-negative to double-positive stages
Runx1 transcription factor is highly expressed at a CD4/CD8-double-negative (DN) stage of thymocyte development but is down-regulated when cells proceed to the double-positive (DP) stage. In the present study, we examined whether the down-regulation of Runx1 is necessary for thymocyte differentiatio...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Published: |
Blackwell Publishing
2010
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| Subjects: |