Relationship betweenABCB1polymorphisms and serum methadone concentration in patients undergoing methadone maintenance therapy (MMT)
Background: Methadone is a substrate of the permeability glycoprotein (P-gp) efflux transporter, which is encoded by the ABCB1 (MDR1) gene. Large interindividual variability in serum methadone levels for therapeutic response has been reported. Genetic variations in ABCB1 gene may be responsible for...
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Taylor & Francis
2016
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