Transcriptome profiling of monocytes from XLA patients revealed the innate immune function dysregulation due to the BTK gene expression deficiency

Transcriptome profiling of monocytes from XLA patients revealed the innate immune function dysregulation due to the BTK gene expression deficiency

X-linked agammaglobulinemia (XLA) is a rare genetic disorder, caused by mutations in BTK (Bruton's Tyrosine Kinase) gene. Deep high-throughput RNA sequencing (RNA-Seq) approach was utilized to explore the possible differences in transcriptome profiles of primary monocytes in XLA patients compar...

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Bibliographic Details
Main Authors: Mirsafian, H., Ripen, A.M., Leong, W.M., Chear, C.T., Mohamad, S.B., Merican, A.F.
Format: Article
Language:English
Published: Nature Publishing Group 2017
Subjects:
Q Science (General)
QH Natural history
Online Access:http://eprints.um.edu.my/18995/1/Transcriptome_profiling_of_monocytes_from_XLA_patients_revealed_the_innate_immune_function_dysregulation_due_to_the_BTK_gene_expression_deficiency.pdf

Internet

http://eprints.um.edu.my/18995/1/Transcriptome_profiling_of_monocytes_from_XLA_patients_revealed_the_innate_immune_function_dysregulation_due_to_the_BTK_gene_expression_deficiency.pdf

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