Loop dynamics behind the affinity of DARPins towards ERK2: Molecular dynamics simulations (MDs) and elastic network model (ENM)
The binding affinity and dynamics profiles of non-phosphorylated extracellular regulated kinase 2 (ERK2), in complex with DARPins (designed ankyrin repeat proteins) as a phosphorylation inhibitor, has been investigated using molecular dynamics simulations (MDs) and elastic network model (ENM). The s...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Published: |
Elsevier
2019
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| Subjects: |