Modification of anti-cancer co-crystal for thymidylate synthase inhibition: Molecular dynamics study
Raltitrexed (tomudex) is an alternative antifolate drug to 5-fluorouracil (5-FU) to inhibit thymidylate synthase (TS) by decreasing dihydrofolate reductase (DHFR) activity. The clinical trial shows the potential of raltitrexed towards TS inhibition can be enhanced by combining the raltiterexed with...
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Faculty of Science, Chiang Mai University
2018
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