Modification of anti-cancer co-crystal for thymidylate synthase inhibition: Molecular dynamics study

Modification of anti-cancer co-crystal for thymidylate synthase inhibition: Molecular dynamics study

Raltitrexed (tomudex) is an alternative antifolate drug to 5-fluorouracil (5-FU) to inhibit thymidylate synthase (TS) by decreasing dihydrofolate reductase (DHFR) activity. The clinical trial shows the potential of raltitrexed towards TS inhibition can be enhanced by combining the raltiterexed with...

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Bibliographic Details
Main Authors:	Sabri, Nadia Hanim, Halim, Siti Nadiah Abdul, Zain, Sharifuddin Md, Lee, Vannajan Sanghiran
Format:	Article
Published:	Faculty of Science, Chiang Mai University 2018
Subjects:	Q Science (General) QD Chemistry

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