Saccharin: an efficient organocatalyst for the one-pot synthesis of 4-amidocinnolines under metal and halogen-free conditions

A mild and efficient protocol for the one-pot synthesis of 4-amidocinnolines was developed using saccharin as a cheap and eco-friendly organocatalyst and t-butyl nitrite as a metal-free diazotization reagent. The current method has advantages such as cost effectiveness, use of the biodegradable reag...

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Bibliographic Details
Main Authors: Khaligh, Nader Ghaffari, Mihankhah, Taraneh, Johan, Mohd Rafie, Juan, Joon Ching
Format: Article
Published: Springer Verlag 2018
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