Saccharin: an efficient organocatalyst for the one-pot synthesis of 4-amidocinnolines under metal and halogen-free conditions
A mild and efficient protocol for the one-pot synthesis of 4-amidocinnolines was developed using saccharin as a cheap and eco-friendly organocatalyst and t-butyl nitrite as a metal-free diazotization reagent. The current method has advantages such as cost effectiveness, use of the biodegradable reag...
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| Format: | Article |
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Springer Verlag
2018
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| author | Khaligh, Nader Ghaffari Mihankhah, Taraneh Johan, Mohd Rafie Juan, Joon Ching |
| author_facet | Khaligh, Nader Ghaffari Mihankhah, Taraneh Johan, Mohd Rafie Juan, Joon Ching |
| author_sort | Khaligh, Nader Ghaffari |
| collection | UM |
| description | A mild and efficient protocol for the one-pot synthesis of 4-amidocinnolines was developed using saccharin as a cheap and eco-friendly organocatalyst and t-butyl nitrite as a metal-free diazotization reagent. The current method has advantages such as cost effectiveness, use of the biodegradable reagents, simple experimental procedure; afford the quantitative yield of the desired products, metal- and halogen-free as well as environmentally benign conditions. |
| first_indexed | 2024-03-06T05:54:42Z |
| format | Article |
| id | um.eprints-21639 |
| institution | Universiti Malaya |
| last_indexed | 2024-03-06T05:54:42Z |
| publishDate | 2018 |
| publisher | Springer Verlag |
| record_format | dspace |
| spelling | um.eprints-216392019-07-16T08:14:08Z http://eprints.um.edu.my/21639/ Saccharin: an efficient organocatalyst for the one-pot synthesis of 4-amidocinnolines under metal and halogen-free conditions Khaligh, Nader Ghaffari Mihankhah, Taraneh Johan, Mohd Rafie Juan, Joon Ching QD Chemistry TA Engineering (General). Civil engineering (General) A mild and efficient protocol for the one-pot synthesis of 4-amidocinnolines was developed using saccharin as a cheap and eco-friendly organocatalyst and t-butyl nitrite as a metal-free diazotization reagent. The current method has advantages such as cost effectiveness, use of the biodegradable reagents, simple experimental procedure; afford the quantitative yield of the desired products, metal- and halogen-free as well as environmentally benign conditions. Springer Verlag 2018 Article PeerReviewed Khaligh, Nader Ghaffari and Mihankhah, Taraneh and Johan, Mohd Rafie and Juan, Joon Ching (2018) Saccharin: an efficient organocatalyst for the one-pot synthesis of 4-amidocinnolines under metal and halogen-free conditions. Monatshefte fur Chemie - Chemical Monthly, 149 (6). pp. 1083-1087. ISSN 0026-9247, DOI https://doi.org/10.1007/s00706-018-2174-2 <https://doi.org/10.1007/s00706-018-2174-2>. https://doi.org/10.1007/s00706-018-2174-2 doi:10.1007/s00706-018-2174-2 |
| spellingShingle | QD Chemistry TA Engineering (General). Civil engineering (General) Khaligh, Nader Ghaffari Mihankhah, Taraneh Johan, Mohd Rafie Juan, Joon Ching Saccharin: an efficient organocatalyst for the one-pot synthesis of 4-amidocinnolines under metal and halogen-free conditions |
| title | Saccharin: an efficient organocatalyst for the one-pot synthesis of 4-amidocinnolines under metal and halogen-free conditions |
| title_full | Saccharin: an efficient organocatalyst for the one-pot synthesis of 4-amidocinnolines under metal and halogen-free conditions |
| title_fullStr | Saccharin: an efficient organocatalyst for the one-pot synthesis of 4-amidocinnolines under metal and halogen-free conditions |
| title_full_unstemmed | Saccharin: an efficient organocatalyst for the one-pot synthesis of 4-amidocinnolines under metal and halogen-free conditions |
| title_short | Saccharin: an efficient organocatalyst for the one-pot synthesis of 4-amidocinnolines under metal and halogen-free conditions |
| title_sort | saccharin an efficient organocatalyst for the one pot synthesis of 4 amidocinnolines under metal and halogen free conditions |
| topic | QD Chemistry TA Engineering (General). Civil engineering (General) |
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