The mechanism of formation, structure and physiological relevance of covalent hemoglobin attachment to the erythrocyte membrane

Covalent hemoglobin binding to membranes leads to band 3 (AE1) clustering and the removal of erythrocytes from the circulation; it is also implicated in blood storage lesions. Damaged hemoglobin, with the heme being in a redox and oxygen-binding inactive hemichrome form, has been implicated as the b...

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Bibliographic Details
Main Authors: Welbourn, Elizabeth M., Wilson, Michael T., Yusof, Ashril, Metodiev, Metodi V., Cooper, Chris E.
Format: Article
Published: Elsevier 2017
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