High performance liquid chromatography of dextromethorphan and its main metabolite in human urine
Dextromethorphan (DM) is 0-demethylated to its main metabolite, dextrorphan (DO), following a polymorphic reaction that depends on the isoenzyme, cytochrome P-il502Di5 [C'i'P2D6). Traditionally, phenotyping of this isoenzyme utilises debrisoquine, individuals with rapid or normal metabolis...
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Faculty of Medicine, University of Malaya
1997
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