Cardiovascular activity of Labdane Diterpenes from andrographis paniculata in isolated rat hearts
The dichloromethane (DCM) extract of Andrographis paniculata Nees was tested for cardiovascular activity. The extract significantly reduced coronary perfusion pressure by up to 24.5 ± 3.0 mm Hg at a 3 mg dose and also reduced heart rate by up to 49.5 ± 11.4 beats/minute at this dose. Five labdane di...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Hindawi Publishing Corporation
2012
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| Online Access: | http://eprints.um.edu.my/3168/1/1.pdf |
| _version_ | 1825718765840498688 |
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| author | Awang, Khalijah Abdullah, N.H. Hadi, A.H. Su Fong, Y. |
| author_facet | Awang, Khalijah Abdullah, N.H. Hadi, A.H. Su Fong, Y. |
| author_sort | Awang, Khalijah |
| collection | UM |
| description | The dichloromethane (DCM) extract of Andrographis paniculata Nees was tested for cardiovascular activity. The extract significantly reduced coronary perfusion pressure by up to 24.5 ± 3.0 mm Hg at a 3 mg dose and also reduced heart rate by up to 49.5 ± 11.4 beats/minute at this dose. Five labdane diterpenes, 14-deoxy-12-hydroxyandrographolide (1), 14-deoxy-11,12-didehydroandrographolide (2), 14-deoxyandrographolide (3), andrographolide (4), and neoandrographolide (5), were isolated from the aerial parts of this medicinal plant. Bioassay-guided studies using animal model showed that compounds, (2) and (3) were responsible for the coronary vasodilatation. This study also showed that andrographolide (4), the major labdane diterpene in this plant, has minimal effects on the heart. |
| first_indexed | 2024-03-06T05:09:22Z |
| format | Article |
| id | um.eprints-3168 |
| institution | Universiti Malaya |
| language | English |
| last_indexed | 2024-03-06T05:09:22Z |
| publishDate | 2012 |
| publisher | Hindawi Publishing Corporation |
| record_format | dspace |
| spelling | um.eprints-31682019-03-08T08:35:30Z http://eprints.um.edu.my/3168/ Cardiovascular activity of Labdane Diterpenes from andrographis paniculata in isolated rat hearts Awang, Khalijah Abdullah, N.H. Hadi, A.H. Su Fong, Y. R Medicine The dichloromethane (DCM) extract of Andrographis paniculata Nees was tested for cardiovascular activity. The extract significantly reduced coronary perfusion pressure by up to 24.5 ± 3.0 mm Hg at a 3 mg dose and also reduced heart rate by up to 49.5 ± 11.4 beats/minute at this dose. Five labdane diterpenes, 14-deoxy-12-hydroxyandrographolide (1), 14-deoxy-11,12-didehydroandrographolide (2), 14-deoxyandrographolide (3), andrographolide (4), and neoandrographolide (5), were isolated from the aerial parts of this medicinal plant. Bioassay-guided studies using animal model showed that compounds, (2) and (3) were responsible for the coronary vasodilatation. This study also showed that andrographolide (4), the major labdane diterpene in this plant, has minimal effects on the heart. Hindawi Publishing Corporation 2012 Article PeerReviewed application/pdf en http://eprints.um.edu.my/3168/1/1.pdf Awang, Khalijah and Abdullah, N.H. and Hadi, A.H. and Su Fong, Y. (2012) Cardiovascular activity of Labdane Diterpenes from andrographis paniculata in isolated rat hearts. Journal of Biomedicine and Biotechnology. ISSN 1110-7243, DOI PMID: 22536026. http://www.ncbi.nlm.nih.gov/pubmed/22536026 PMID: 22536026 |
| spellingShingle | R Medicine Awang, Khalijah Abdullah, N.H. Hadi, A.H. Su Fong, Y. Cardiovascular activity of Labdane Diterpenes from andrographis paniculata in isolated rat hearts |
| title | Cardiovascular activity of Labdane Diterpenes from andrographis paniculata in isolated rat hearts |
| title_full | Cardiovascular activity of Labdane Diterpenes from andrographis paniculata in isolated rat hearts |
| title_fullStr | Cardiovascular activity of Labdane Diterpenes from andrographis paniculata in isolated rat hearts |
| title_full_unstemmed | Cardiovascular activity of Labdane Diterpenes from andrographis paniculata in isolated rat hearts |
| title_short | Cardiovascular activity of Labdane Diterpenes from andrographis paniculata in isolated rat hearts |
| title_sort | cardiovascular activity of labdane diterpenes from andrographis paniculata in isolated rat hearts |
| topic | R Medicine |
| url | http://eprints.um.edu.my/3168/1/1.pdf |
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