C-kit protein expression correlated with activating mutations in KIT gene in oral mucosal melanoma
C-kit is a trans-membrane receptor tyrosine kinase (RTK) encoded by the proto-oncogene KIT located at 4q11-12. Gain-of-function mutations arising to c-kit activation independent of its ligand were observed in various tumors related to germ cells, mast cells, and interstitial cells of Cajal. C-kit al...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
2008
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| Subjects: | |
| Online Access: | http://eprints.um.edu.my/4310/1/C-kit_protein_expression_correlated_with_activating_mutations_in_KIT_gene_in_oral_mucosal_melanoma.pdf |