The influence of CYP3A gene polymorphisms on cyclosporine dose requirement in renal allograft recipients
Cyclosporine is a substrate of cytochrome P-450 3A (CYP3A) subfamily of enzymes and characterized by a narrow therapeutic range with wide interindividual variation in pharmacokinetics. A few single-nucleotide polymorphisms detected in CYP3A genes have been shown to correlate significantly with the C...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Published: |
2006
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| Subjects: |