The influence of CYP3A gene polymorphisms on cyclosporine dose requirement in renal allograft recipients

The influence of CYP3A gene polymorphisms on cyclosporine dose requirement in renal allograft recipients

Cyclosporine is a substrate of cytochrome P-450 3A (CYP3A) subfamily of enzymes and characterized by a narrow therapeutic range with wide interindividual variation in pharmacokinetics. A few single-nucleotide polymorphisms detected in CYP3A genes have been shown to correlate significantly with the C...

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Bibliographic Details
Main Authors:	Eng, H.S., Mohamed, Z., Calne, R., Lang, C.C., Mohd, M.A., Seet, W.T., Tan, S.Y.
Format:	Article
Published:	2006
Subjects:	R Medicine

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