Suggested improved method for the ing-manske and related reactions for the second step of gabriel synthesis of primary amines
This work demonstrates an improvement in the Ing-Manske and related procedures by the increase of pH of the reaction mixture after the complete disappearance of N-substituted phthalimide. Hydrazinolysis of N-phenylphthalimide (1a) gave 80% of the desired primary amines after 5.3 h in the absence of...
| Main Authors: | , , , , |
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| Format: | Article |
| Published: |
2004
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| Subjects: |