Kinetics and mechanism of large rate enhancement in an Acidic Aqueous Cleavage of the Tertiary Amide Bond of N-(2-Methoxyphenyl)-N'-Morpholinophthalamide (1)
The rate of conversion of 1 to N-(2-methoxyphenyl)phthalimide (2) within [HCI] range 5.0 x 10(-3)-1.0 M at 1.0 M ionic strength (by NaCl) reveals the presence of both uncatalyzed and specific acid-catalyzed kinetic terms in the rate law. Intramolecular carboxamide group-assisted cleavage of amide bo...
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| Format: | Article |
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2008
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